Post Cycle Therapy

Post Cycle Therapy (PCT) - What is it and do I need it actually?

Steroids: In the world of sport, steroids are most likely the most controversial and
most discussed topic ever. The discussion covers bodybuilders with the help of
Anabolic steroids have become the biggest action heroes, all the way to prestigious ones
World class athletes who are push...

Post Cycle Therapy (PCT) - What is it and do I need it actually?

Steroids: In the world of sport, steroids are most likely the most controversial and
most discussed topic ever. The discussion covers bodybuilders with the help of
Anabolic steroids have become the biggest action heroes, all the way to prestigious ones
World class athletes who are pushed off their pedestal because of their use
performance-enhancing substances. Since Ben Johnson during the Olympics
Steroids are common in most discussions in 1988, as demonstrated by banned substances
Focus on the future of sport.
How does modern society face this topic?
Recent events - such as the Lance Armstrong case - are having anew this debate
ignited, in particular, the moral responsibility or their lack
which is related to the use of performance-enhancing substances, as well as the dangers
that accompany this practice.
For many panelists this is a forbidden topic. The prejudices and myths about the
Using anabolic steroids have made their use a taboo, "something
what you just do not talk about ".
Nevertheless, it is well known that many weight lifters and bodybuilders of anabolic steroids and
other performance-enhancing substances are dependent because they are at the top of their sport
want.
In the midst of the controversy over this issue, there are always contradictory and passionate ones
Opinions that range from the conventional viewpoint that steroids a
Pose a health risk and an unfair advantage to the athletes who use them, right through to
Defenders, who demand a legalization and control of these substances, with the pretext that only
to allow control and transparency of this problem. Recently defended, Ellis
Cashmore, a professor of culture, media and sports at Staffordshire University in the UK, in
an article for CNN this latter approach [* 1].
No matter how your attitude to this topic is, one fact is incontrovertible: the use of
Anabolic steroids are quite common in the world of weightlifting and bodybuilding. And though Prozis
We do not sell any anabolic steroids and in no way defend the use of these substances
the opinion that this topic alone under the aspect of public health
must be discussed. The more information we have about this topic, the more
we can handle it better, and make informed decisions on the basis of scientific
Take data.

If PCT is a therapy, what should it treat?
In addition to the article on steroids, which has already been published on this blog, is now the
right time to address the second stage of the use of steroids: the post-cyclical
Therapy, also known as PCT (Post Cycle Therapy).
When an athlete completes an anabolic steroids intake cycle, another begins
decisive phase for him, the post-cyclic therapy. The PCT serves two main purposes.
The first is to make sure the athlete has the muscles built up during the intake cycle
can receive; the second is to prevent the post-cyclical collapse that affects him
would probably cost some of the hard-earned muscle. Unfortunately this is easier said than
done, given the concentrations of hormones and other substances that are in the body during the cycle
present (such as testosterone, the insulin-like growth factor, growth hormones, etc.),
change now.
Unfortunately, athletes have less hormone levels available at this time
which are needed for building muscle - instead, are now higher levels of the catabolic
Hormones present. At this point it is important to start producing your own as soon as possible
stimulate natural anabolic hormones and less of the catabolic hormones
distribute. So far so good - but how can you achieve that? Here you read the exact
Description of the process.
First things first: Which hormones are we talking about? To be an effective PCT
First, steroid users must consider the fact that
different substances also require different PCT approaches as they are different
Cause effects in the body.
If you are considering starting an anabolic steroid cycle, you should be absolutely sure about the
Properties of the selected substance so that you can customize your PCT accordingly,
when this cycle is completed. For this purpose, here is a short list of relevant ones
Circles most popular anabolic steroids:
The DHT derivatives, to this group include

1-testosterone, methasterone - also known as superdrol - and methyl-1-testosterone.

The testosterone derivatives include testosterone and its esters, methyltestosterone, boldenone and its esters, metandienone, bolasterone, 4-androstenediol, and 4-androstenedione 19-norderivatives, such as trenbolone, nandrolone, norandrostenedione and norandrostenediol.

The PCT programs for the above mentioned substances have several similarities, since they are used in situations that often occur in a similar manner when using one of these steroid. The most important aspect of a post-cyclic therapy is the restoration of the body's own endogenous testosterone production. That's the biggest worry a user of anabolic steroids needs to keep in mind. Look at it this way: when an athlete starts a program that shoots his testosterone levels up to the roof for a few months, he has to make sure that the subsequent crash will not endanger his health or his built-up muscles. After all, this is about something as important as hormones!

You can not expect your body to enter a temporary state of muscle overdevelopment for 3 or 4 months and then, suddenly, resume where it was before. Actually, in this case, the human body is very strong messed up is. Ignoring the effects of such a hormonal imbalance can lead to undesirable results and even be dangerous. And that is why steroid users need this therapy, namely to guide the body through the normalization process and not leave it in a hormonal state of chaos.

What aspects are relevant in post-cyclic therapy?

Essentially, there are four aspects: the axis by which is meant the hypothalamic-pituitary-testicular axis, or HPTA for short. This system controls and controls the body's natural testosterone production. When the system detects a need for more testosterone, it releases the gonadotropin releasing hormone (also known as GnRH). If it detects too much testosterone in the body, it forwards negative feedback to the hypothalamus and pituitary, which then causes the release of estrogen to restore balance. An excessive amount of estrogen then does exactly the opposite of what creates an excess of testosterone. In extreme cases, men then experience symptoms such as breastfeeding, a female voice, and other symptoms indicative of excess estrogen in the body.

An effective PCT, on the other hand, keeps the estrogen production under control. Looking at the testicles. Yes, that's right, we're talking about the testicles now. Testicular desensitization is a problem that affects steroid users. Since the testes produce testosterone, one must ensure that this production returns to a normal level once the cycle of steroid use is complete.

An effective PCT prevents testicular atrophy (regression) and suppression of testosterone release. Help, estrogen threatens !! Antiestrogens are substances that play an important role in any PC program because they regulate estrogen levels in the body. After a steroid cycle, the body is at risk of hormonal imbalance, which often increases estrogen levels. This phenomenon is called aromatase.

And this is how the aromatase process works: over a period of time, the steroid user has ensured that his testosterone levels are very high, resulting in increased buildup of muscle mass. The only problem here is that the body reacts by producing more estrogen, the "female" hormone, to balance testosterone levels. If someone decides to use a testosterone product, the body will tend to produce more estrogen to keep up with the increase in testosterone. However, once the testosterone cycle is completed, he or she must undergo post-cycle therapy consisting of anti-estrogens to inhibit aromatase and to ensure normalized estrogen levels.

Human chorionic gonadotropin. Known as HCG. This is a specific injectable drug that must be resorted to when treatment with antiestrogens is no longer effective. HCG is essentially a prescription fertility enhancer that mimics the body's natural luteinizing hormone. The administration of HCG abruptly activates the testes by an overwhelmingly high luteinizing hormone presence, which allows the user a hormone level that the body can reach impossible without this intervention or only with the help of the antiestrogens.

Buy Post Cycle Therapy substances like Clomiphene, Tamoxifen and HCG healthy and effective.

More

Post Cycle Therapy  There are 9 products.

Subcategories

  • Anastrozole

    1. What are Anastrozole film-coated tablets and what for
    are they used?


    Anastrozole contains an active substance, the anesthetic
    trozole is called. This belongs to a group of drugs
    means "aromatase inhibitor". Anastrozole - 1 A Pharma
    1 mg is used to treat breast cancer in women after
    Menopause applied.
    Anastrozole works by keeping the
    lowers the amount of the hormone estrogen produced. This is
    happens by inhibition of a natural substance (an
    zyms) in your body called "aromatase".


    2. What should you do before taking of Anastrozole Pay attention to film-coated tablets?


    Anastrozole must not be taken
    • if you are allergic to anastrozole or one of the in section
    6 other ingredients of this medicine
    • if you are pregnant or nursing (see section
    "Pregnancy and breast feeding period")
    Do not take Anastrozole if one
    the above points applies to you. If you are unsure
    are, ask your doctor or pharmacist before taking anastrozole -
    1 A Pharma Take 1 mg.
    Warnings and Precautions
    Check with your doctor or pharmacist before taking
    Anastrozole
    • whether you still have your menstruation and your menopause
    are not over yet.
    • whether you are taking a medicine containing tamoxifen,
    or taking medicines containing estrogen (see
    Section "Taking Anastrozole with
    other medicines ")
    • if you have ever had a condition that affects your strength
    Affecting your bones
     
    was usst (osteoporosis).
    • if you have liver or kidney dysfunction.
    If you are not sure if any of the above
    Points to you, talk to you before taking
    trozol - 1 A Pharma 1 mg with your doctor or pharmacist.
    If you need to go to the hospital, inform the medical
    staff that you have Anastrozole
    taking. Effects of misuse for doping purposes
    The use of the drug Anastrozole
    can lead to positive results in doping controls.
    Taking Anastrozole with
    other medicines
    Please inform your doctor or pharmacist if you have others
    Taking or recently taking medicine
    even if it is not prespec
    essential medicines
    acts. This includes medicines you do without a prescription
    can buy, and plow medicinal products. The reason for that
    Anastrozole has the effect of some
    influence the food may and that some medicines
    on Anastrozole - 1 A Pharma may have 1 mg.
    Do not take Anastrozole if you
    already take one of the following medicines:

    • Certain medicines used to treat breast cancer
    (selective estrogen receptor modulators),
    z. For example, medicinal products containing tamoxifen. The reason for that
    is that these medicines may cause Anastrozole to stop working properly.
    • medicines containing estrogen, as in a hormone
    replacement therapy (HET)
    If this applies to you, ask your doctor or pharmacist
    for advice.
    Talk to your doctor or pharmacist if you following
    Take medicines:
    • Medicines known as "LHRH analogue". In addition,
    listen to Gonadorelin, Buserelin, Goserelin, Leuprorelin and Tripto-
    relin. These medicines are used to treat breast cancer,
    certain female (gynecological) diseases and
    Infertility applied.
    pregnancy and breast feeding period
    You are allowed to take Anastrozole
    do not take
    if you are pregnant or breastfeeding. Break the intake
    Anastrozole if you become pregnant
    and talk to your doctor.
    Ask your doctor before taking this medicine
    or pharmacists for advice.
    Driving and using
    of machines
    It is unlikely that Anastrozole
    Ability to drive a vehicle or tools or machinery.
    to operate. However, some people feel
    patients treated with Anastrozole - 1 A Pharma
    1 mg occasionally weak or drowsy. If this is yours
    If this occurs, ask your doctor or pharmacist for advice.
    Anastrozole contains lactose,
    a certain type of sugar.
    Please take this medicine only after consultation
    Your doctor, if you know that you have an accident.
    ckeranverträglichkeit suffer.

    3. How to take anastrozole?

    Always take this medicine exactly as directed
    of the doctor. Please ask your doctor or pharmacist
    after, if you are not sure.
    • The usual dose is one tablet once a day.
    • Try to take your tablet at the same time every day.
    • Swallow the tablet whole with water.
    • It does not matter if you have Anastrozole before,
    during or after a meal.
    Take Anastrozole for as long as it takes
    Your doctor recommends
     
    EHLT. The treatment is a long-term therapy
    and it may be that you have been taking this medicine for several years
    need to take.
    Use in children
    Anastrozole should be used in children and adolescents.
    not be used.
    If you use a larger amount of anastrozole -
    1 A Pharma 1 mg taken when you
    If you use a larger amount of Anastrozole
    have taken as you should, please notify
    your doctor immediately.
    If you forget to take Anastrozole
    If you forget to take one, take it
    next dose as normal. Do not take the double
    Dose (2 tablets at once) if you have
    forgot.

    4. Which side effect has anastrozole?

    Very common side effects (may affect more than 1 person
    of 10)
    • A headache
    • hot flashes
    • nausea
    • Skin rash
    • joint pain or stiffness
    • inflammation in the joints (arthritis)
    • feeling weak
    • decrease in bone density (osteoporosis)
    Common side effects (may affect up to 1 in 10 people
    affect)
    • loss of appetite
    • Increased or high levels of a fatty substance in your blood that
    is called cholesterol. This may be due to a blood
    be determined
    • drowsiness
    • carpal tunnel syndrome (tingling, pain, feeling cold,
    Weakness in parts of the hand)
    • diarrhea
    • Vomiting
    • Changes in blood tests that show how well your liver works.
    • thinning hair (hair loss)
    • Allergic (overdelivery
     
    reactions), which are also
    sight, lips or tongue
    • bone pain
    • Dry sheath
    • vaginal bleeding (usually in the first few weeks
    the treatment - if the bleeding stop, talk
    with your doctor)
    • Muscle aches
    Uncommon side effects (up to 1 in 100 users)
    concern)
    • Changes in special blood tests that show how yours
    Liver works (gamma-GT and bilirubin)
    • inflammation of the liver (hepatitis)
    • rash or hives
    • quick finger (a condition in which your finger or
    in a bent position)
    • Increasing the level of calcium in your blood. If with you
    Nausea, vomiting or thirst should occur, you should contact
    Your doctor, pharmacist or nurse
    because your blood values ​​may need to be checked.
    Rare side effects (may affect up to 1 in 1,000 people)
    concern)
    • Rare dermal inflammation, red spots or blistering
    may include
    • rash caused by overdosage
     
    identity (the
    Cause can be an allergic or allergic reaction)
    • Inflammation of the small blood vessels that turn to red or purple
    Discoloration of the skin leads. Very rarely, joint, stomach and
    and kidney pain as discomfort; these new
    benwirkungen is called "Purpura Schoenlein-Enoch".
    Very rare side effects (up to 1 in 10,000
    concern)
    • Extremely severe skin reaction with ulcers and blisters
    on the skin. This is called "Stevens-Johnson Syndrome"
    designated.
    • Allergic (overdelivery
      
    reactions) with threshold
    throat, difficulty swallowing or breathing
    cause. This reaction is called "angioedema".
    If any of these signs occur to you, you must immediately
    Call an ambulance or see a doctor as you
    urgently need medical treatment.
    Affect your bones
    Anastrozole lowers the amount of the hormone estrogen
    rogen in your body. This can change the mineral content of your bones
    reduce. Your bones can lose strength and more
    tend to break faster. Your doctor will meet these risks.
    according to the treatment guidelines for the maintenance of bone health
    treat women after menopause. You should be with yours
    Doctor talk about the risks and treatment options.

    5. How to store anastrozole?

    There are no special storage conditions for this medicine.
    conditions required.
    Store drug out of reach of children. Store
    Keep the tablets in a safe place that is not visible to children.
    is bar and they can not reach. Your tablets can
    Harm you.
    You may use the medicinal product according to the box on the carton.
    no longer apply the expiration date. The expiry date is
    retires on the last day of the month.
    Store the tablets in the container in which you place them
    have received.
    Do not dispose of medicines in wastewater or household
    waste. Ask your pharmacist how to use the medicine.
    Worry is when you stop using it. You wear it
    to protect the environment.

  • Clomiphene

    Buy Clomiphene citrate | Clomid Shop

    Active substance name: Clomiphene citrate

    Trade Names: Dyneric, Clomid, Omifin, Clomiphene Citrate

    Dosage Form: Tablets 50mg

    Side effects: Hot flashes, depression, tiredness and nausea

    Clomiphene characteristics & mode of action:

    Clomiphene is neither an anabolic steroid nor an androgenic steroid.

    What is Clomiphene?

    The active ingredient Clomiphene is a synthetic estrogen that is usually prescribed to women who want to have children. Bodybuilders use clomiphene because it boosts natural testosterone production. Bodybuilders often take advantage of this effect after an anabolic steroid cycle to start the testosterone production. Clomiphene increases LH and FSH secretion. This mechanism restarts your own testosterone production.

    How to use Clomiphene after an anabolic steroid cycle?

    So that the effect of Clomiphene really does reach the desired effect, the intake of the active substance should be tailored to the steroids used previously in the anabolic steroids. It is important to know what half-life the previously ingested products had. Assuming a half-life of a maximum of one day, can be started with the intake of Clomiphene directly on the following day. For a long time, it was assumed that the use of clomiphene after an anabolic cycle was not necessary, this opinion has changed. Because every anabolic androgenic steroid reduce the body's own production of testosterone and the bodybuilder after the end of the cycle threatens to lose all the mass and strength gains, so the intake of clomiphene makes sense. Clomiphene may also be used during a course of treatment to maintain testicle size and amount of ejaculate. In this case, however, the application must be started directly at the beginning of the cycle. Clomiphene can help to maintain the size of the testicles and is able to resize already reduced testicles. Applying clomiphene to gain muscle does not make sense. The effect of the synthetic estrogen is limited to the testosterone balance.

    What side effects does Clomiphene have?

    Rarely, skin allergic reactions, hot flushes, nervousness, insomnia, drowsiness, depression, fatigue, visual disturbances in the form of eye fibrillation, nausea and vomiting occur. These disappear after use.

  • Exemestane

    1. What is Exemestane and what is it used for?


    Exemestane belongs to a group of medicines known as aromatase inhibitors. These medicines affect an aromatase called substance, which is needed to produce the female sex hormones (estrogens), especially in postmenopausal women. Reducing estrogen levels in the body is one way to treat hormone-dependent breast cancer.

    Exemestane is indicated for the treatment of postmenopausal women with early hormone-dependent breast cancer after 2 to 3 years of tamoxifen initial therapy.

    Exemestane is also indicated for the treatment of postmenopausal women with advanced hormone-dependent breast cancer who have not received enough other hormone therapy.

    2. What you need to know before you take Exemestane?
    Exemestane should not be taken

        if you are allergic (hypersensitive) to exemestane or any of the other ingredients of Exemestane. Refer to Section 6 for the full list of excipients.
        
    if you have not yet passed the "menopause" d. h., if you still have your monthly menstrual period.
        
    if you are pregnant, may be pregnant or breastfeeding.

    Take special care with Exemestane

        
    Before taking Exemestane, your doctor may want to do a blood test to make sure you are out of the menopause.

        
    If you have liver or kidney problems, tell your doctor before taking Exemestane.
        
    Tell your doctor if you have any medical conditions or conditions that affect your bone density. Your doctor may determine your bone density before and during treatment with Exemestanatiopharm® 25 mg. This is important because the drugs of this group lower the female hormone levels, which can reduce the mineral content of the bones and amit can lead to a reduction in their strength.

    When taking Exemestane with other medicines

    Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

    Exemestane should not be taken with hormone replacement therapy. Talk to your doctor if you are taking any of the following medicines:

        
    Rifampicin (an antibiotic)
        
    Medicines for epilepsy (carbamazepine or phenytoin)
        
    herbal medicines for depression (St. John's wort [Hypericum perforatum])

    Taking Exemestane with food and drink

    Exemestane should be taken at approximately the same time every day after a meal.
    pregnancy and breast feeding period

    Do not take Exemestane if you are pregnant or breast-feeding. If you are pregnant or suspect talk to your doctor. Consult your doctor for contraception if there is a possibility that you might become pregnant.

    Ask your doctor or pharmacist for advice before taking / using any medicine.
    Driving and using machines

    If you feel drowsy, dizzy or weak while taking Exemestane, you should not try to drive a car or operate machinery.
    Effects of misuse for doping purposes

    The use of Exemestane may give positive results in doping controls. The use of Exemestane as a doping agent may endanger your health.

    3. How to take Exemestane?


    Exemestane should be taken at approximately the same time every day after a meal.

    Always take Exemestane exactly as your doctor has told you. Please check with your doctor or pharmacist if you are not sure.

    The usual dose is 1 tablet (25 mg) per day.

    If you need to go to the hospital while taking Exemestane, tell the medical staff which medicine you are taking.
    children

    Exemestane is not indicated for use in children.
    If you take more Exemestan ratiopharm 25 mg than you should

    If you accidentally take too many tablets, contact your doctor immediately or go to the nearest hospital outpatient clinic. Show the package of Exemestane.
    If you forget to take xemestan-ratiopharm® 25 mg

    Do not take a double dose if you have forgotten the previous tablet. If you forget to take your tablet, take it as soon as you notice it. If it is already time for the next dose, take it at the usual time.
    If you stop taking Exemestane

    Do not stop taking your tablets, even if you feel well, unless your doctor tells you to.

    If you have any further questions on the use of the medicine, ask your doctor or pharmacist.

    4. What side effects are possible from exemestane?


    Like all medicines, Exemestane can cause side effects, although not everybody gets them. Exemestane is well tolerated and the following side effects observed in patients treated with exemestane are usually mild or moderate. Most side effects are due to an estrogen deficiency (eg hot flashes).

    The following side effects have been reported:
    Very common side effects (affects more than 1 in 10 patients)

        
    sleep disorders
        
    a headache
        
    hot flashes
        
    nausea
        
    increased sweating
        
    Muscle and joint pain (including osteoarthritis, back pain, arthritis and joint stiffness)
        
    fatigue

    Common side effects (affects 1 to 10 patients in 100)

        
    anorexia
        
    depression
        
    Dizziness, carpal tunnel syndrome (a combination of ants running, numbness and pain in the whole hand, except the little finger)
        
    Stomach pain, vomiting, constipation, indigestion, diarrhea
        
    Rash, hair loss
        
    Bone loss, which may reduce stability (osteoporosis). This leads in some cases to fractures (bone fractures, cracking)
        
    Pain, swollen hands and feet

    Uncommon side effects (affects 1 to 10 patients in 1,000)

        
    sleepiness
        
    muscle weakness

    Inflammation of the liver (hepatitis) can occur. The signs are general malaise, nausea, jaundice (yellowing of skin and eye white), itching, right abdominal pain and loss of appetite. Contact your doctor immediately if you notice any of these symptoms.

    If you have blood tests, it may be that you notice a change in your liver function. Changes in the number of certain blood cells (lymphocytes) and luteal platelets may occur, especially in patients with already reduced blood lymphocytes (lymphopenia).

    If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

    5. How to store Exemestane?


         Store drug out of reach of children.
         You must not use the medicine after the expiry date which is stated on the carton and blister packs. The expiration date refers to the last day of the month.
         This medicinal product does not require special storage conditions.
         The medicinal product must not be disposed of in waste water. Ask your pharmacist how to dispose of the medicine when you no longer need it. This measure helps to protect the environment.

     

     

     

  • HCG

    1. What is HCG 5000 I.E. and what is it used for?


    The active ingredient of HCG 5000 I.E. belongs to the group of gonadotropins (sex hormones) that regulate the release of egg cells from the ovary in women and in men the production of the male hormone testosterone.

    HCG 5000 I.E. contains as active ingredient chorionic gonadotropin (hCG) - a protein hormone, which is obtained from the urine of pregnant women. Gonadotropins play an important role in fertility and reproduction.

    women

        
    HCG 5000 I.E. is used in female infertility to induce ovulation (ovulation triggering).
        
    HCG 5000 I.E. is also used in conjunction with other fertility medicines to support the production of oocytes in the context of assisted reproduction (IVF).

    Men

        
    HCG 5000 I.E. is used in men to assess the functioning of the testes in the case of sub-function of the sex organs due to a lack of sex hormones before a stimulation therapy.

    children

        
    HCG 5000 I.E. is used in boys with late onset puberty (pubertas tarda).

    2. What should you do before using HCG 5000 I.E. note?


    HCG 5000 I.E. may not be used

        
    If you are allergic to chorionic gonadotropin or any of the other ingredients of this medicine (listed in section 6)
        
    in tumors of the hypothalamus (part of the diencephalon) or the pituitary (pituitary gland)
        
    if you have enlargement of the ovaries or one or more ovarian cysts that are not based on polycystic ovarian syndrome
        
    if you have bleeding of unexplained cause from the vagina
        
    if you have had ovarian, uterine or breast cancer
        
    if you had an ectopic pregnancy within the last three months
        
    if you have severe phlebitis or blood clots in the veins (active thromboembolic disease)
        
    if you have ovarian hyperstimulation syndrome (OHSS - ovarian hyperstimulation syndrome)
        
    if normal pregnancy is not possible for organic reasons, e.g. malfunction of the ovaries, malformations of the reproductive organs that are not compatible with pregnancy, or in connective tissue tumors, or if you have already reached the menopause
        
    if you have sex hormone-dependent tumors, such as Prostate cancer or breast cancer (in men) known or suspected,

    Warnings and Precautions

    Please talk to your doctor or pharmacist before using HCG 5000 I.E. apply.

    Tell your doctor if you have or have had any of the following conditions because of the use of HCG 5000 I.E. can lead to a deterioration:

        
    Cardiovascular disease
        
    kidney disease
        
    Epilepsy (epilepsy)
        
    Migraine-like headache

    Treatment with HCG 5000 I.E. can increase the risk of thrombosis. A thrombosis is the formation of a blood clot in a blood vessel, usually in the veins of the legs or lungs. Even the pregnancy itself can be an increased risk for the occurrence of thrombosis. Please contact your doctor before using HCG 5000 I.E. start when

        
    You already know that you have an increased risk of thrombosis
        
    You or someone from your close relationship already had a thrombosis
        
    You are severely overweight

    Before your doctor begins treatment, the causes of your infertility or that of your partner, and possible contraindications for pregnancy, must be clear. Your doctor must conduct a thorough examination to rule out changes in the genitals or non-gonadal hormonal imbalances (such as thyroid, adrenals or pituitary gland disorders).

    During treatment, close monitoring by your doctor is very important. Usually, ultrasound examinations are performed at regular intervals and blood is collected. This is especially important as you are treated by treatment with HCG 5000 I.E. are at increased risk of developing Ovarian Hyperstimulation Syndrome (OHSS) (see also section 4 "Possible side effects"). This happens when the ovaries overreact to treatment and produce too many follicles. As a rule, an OHSS returns automatically during the menstrual period. OHSS can be more severe and protracted after pregnancy. Therefore, medical checks are recommended for at least two weeks after hCG application.

    Symptoms of mild and moderate OHSS are:

        
    Abdominal pain or discomfort
        
    bloated stomach
        
    nausea
        
    Vomit
        
    diarrhea
        
    increase in weight

    In severe cases of OHSS, additional symptoms may occur such as:

        
    difficult breathing
        
    reduced urination

    Very rarely, complications such as ovarian rotation and blood clots in veins or arteries can occur in severe cases of OHSS.

    Talk to your doctor immediately, even if the symptoms do not appear until a few days after the last injection. These may be signs of increased ovarian activity that could become severe. If these symptoms become severe, treatment for infertility must be stopped and you need to be treated in the hospital.

    Adherence to the recommended dosage and careful monitoring of your treatment reduce the risk of these symptoms.
    Patients with ovarian dysfunction with increased follicle formation (polycystic ovarian syndrome) are at increased risk for OHSS.

    If gonadotropin therapy leads to pregnancy, the likelihood of having twins or multiple births is increased.

    The number of miscarriages both in patients who do not or not enough oocytes, as well as in women who undergo a technique of assisted reproduction, such as. IVF, is higher than the average population, but comparable to the miscarriage rates in women with other fertility disorders.

    In women with premature fallopian tubes, there is a slightly increased risk of ectopic pregnancy.

    The incidence of malformations following assisted reproductive technology may be slightly higher than with natural conception. This may be related to different preconditions in the parents (for example, age of the mother, sperm quality) and the increased incidence of multiple pregnancies.

    Your doctor will especially monitor you during treatment if you have a clinically significant illness that could lead to a worsening of your condition.

    After the application of HCG 5000 I.E. It can lead to a false positive pregnancy test for up to 10 days.

    children
    To avoid bone problems or premature puberty, HCG 5000 I.E. be used with caution in boys before puberty. Skeletal development should be monitored regularly.
    Effects of misuse for doping purposes

    The application of HCG 5000 I.E. can lead to positive results in doping controls.
    The application of HCG 5000 I.E. as a doping agent can lead to a risk to health.
    Application of HCG 5000 I.E. with other medicines

    Tell your doctor or pharmacist if you are taking, have recently taken or might take or intend to take any other medicines.

    Interactions with other medicinal products are unknown.
    Pregnancy, breastfeeding and fertility

    HCG 5000 I.E. is used to treat infertility (see section 1 "What is HCG 5000 I.E. and what is it used for?").

    HCG 5000 I.E. should not be used during pregnancy and breast-feeding.

    3. What is HCG 5000 I.E. apply?

    Always use this medicine exactly as your doctor has told you. Ask your doctor if you are not sure.
    Type of application:

    This medicine is given to you by a doctor experienced in the treatment of fertility problems in a muscle.

    To induce ovulation and stimulation of the ovaries:
    The recommended dose is once 5000 I.E. or 10,000 I.E. hCG (equivalent to 1 or 2 vials HCG 5000 I.E.). The application should take place 24 to 48 hours after reaching the optimal stimulation of the ovaries.
    When HCG 5000 I.E. It is recommended to have sexual intercourse on the day of injection and the following day to induce ovulation after stimulation of the ovaries.

    Verification of the functioning of the testes in case of subfunction of the sexual organs due to a lack of sex hormones:
    The recommended dose is once 5000 I.E. hCG (equivalent to 1 vial of HCG 5000 I.E.).

    children
    In boys with late puberty:
    The recommended dose is: 5000 I.U. hCG (equivalent to 1 vial of HCG 5000 I.U.) weekly for 3 months.

    In boys who have no testicles, or in boys with only one testicle (differential diagnosis of undescended testes):
    The recommended dose is once 5000 I.E. hCG (equivalent to 1 vial of HCG 5000 I.E.).
    If you use a larger quantity HCG 5000 I.E. have applied as you should

    No cases of acute overdose have been reported. However, there is a possibility that in women overdose may trigger ovarian hyperstimulation syndrome (see section 2 "What you should know before you use HCG 5000 I.E.").
    When using the HCG 5000 I.E. have forgotten

    Do not apply twice the amount if you have forgotten the previous application. Talk to your doctor.
    When using the HCG 5000 I.E. abort, stop

    Talk to your doctor.

    4. What side effects are possible frpm HCG 5.000 i.E.?


    Like all medicines, this medicine can cause side effects, although not everybody gets them.

    Hormones for the treatment of infertility, e.g. The hCG in HCG 5000 I.E., may cause increased activity in the ovaries and lead to ovarian hyperstimulation syndrome (OHSS). Symptoms may include abdominal pain, bloated stomach, nausea, vomiting, diarrhea, and weight gain. In severe cases of OHSS, fluid accumulation in the abdomen, pelvis and / or chest cavity, labored breathing, and decreased urination may occur. Rare complications such as blood clots in blood vessels (thromboembolism) and ovarian rotation (ovarian torsion) have been reported in severe cases of OHSS. If you notice any of these symptoms, contact your doctor immediately, even if the symptoms do not appear until a few days after the last injection.

    Allergic reactions (hypersensitivity reactions) may occur in connection with the application of HCG 5000 I.E. occur. Symptoms may include rash, itching, swelling of the throat and labored breathing. If you notice these symptoms, contact your doctor immediately.

    Very common: may affect more than 1 in 10 people

        
    Enlargement of male mammary glands (gynecomastia)
        
    a headache
        
    Reactions and pain at the injection site

    Common: may affect up to 1 in 10 people

        
    Nausea, abdominal pain, vomiting
        
    mild to moderate overstimulation syndrome of the ovaries (OHSS), swelling of the chest, testicular pain
        
    Hot flashes (only observed in men)
        
    Rash, seborrhea (acne vulgaris)

    Uncommon: may affect up to 1 in 100 people

        
    diarrhea
        
    Disruption of salts and water
        
    severe overstimulation syndrome of the ovaries (OHSS)
        
    Depression, irritability, restlessness

    Not known (frequency can not be estimated from the available data):

        
    Hypersensitivity reactions (allergic reactions)
        
    Formation of blood clots in blood vessels
        
    bloated stomach
        
    Rash, itchy hives (hives), itching
        
    Sensitivity and pain in the chest
        
    Fever, fatigue (fatigue), weakness (asthenia)

    Increases in size of the male limb with tendency to stiffening or enlargement of the prostate gland were observed.

    Additional side effects in children and adolescents
    Occasionally, mild psychological changes may occur in boys during treatment, as observed at the beginning of puberty (adolescent behavior).

    5. How is HCG 5000 I.E. Storing?


    Keep this medicine out of the sight and reach of children.

    You must stop using the medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of the specified month.

  • Letrozole

    1. What is Letrozole and what is it used for?


    Letrozole contains the active substance letrozole. It belongs to a group of medicines called aromatase inhibitors. It is a hormonal (or "endocrine") treatment for breast cancer. The growth of breast cancer is often stimulated by estrogens (female sex hormones). Letrozole reduces the amount of estrogen by inhibiting an enzyme involved in the formation of estrogen (the "aromatase") and thus can block the growth of breast cancer that requires estrogen for its growth. As a result, tumor cells stop growing or grow more slowly and / or spreading of the tumor cells into other parts of the body is prevented or slowed down.
    What is Letrozole used for?
    Letrozole is used to treat breast cancer in postmenopausal women (after cessation of menstrual bleeding).
    Letrozole is used to prevent recurrence of breast cancer. It may be used either as a first treatment before breast surgery if immediate surgery is not appropriate, as a first treatment after breast surgery or after a five-year treatment with the drug tamoxifen. etrozolratiopharm ® 2.5 mg is also used to prevent the spread of breast cancer to other parts of the body in patients with advanced disease.
    If you have questions about the effects of Letrozole or would like to know why you were prescribed this medicine, ask your doctor.

    2. What should you watch out for before taking Letrozole?

    Please follow exactly the instructions of your doctor. These instructions may differ from the general information in this leaflet.

    Letrozole should not be taken,

        
    if you are allergic to letrozole or any of the other ingredients of this medicine (listed in section 6).
        
    if you still have menstrual bleeding, d. h., if you have not gone through the menopause (menopause),
        
    if you are pregnant,
        
    when you breastfeed.

    If any of these statements apply to you, please do not take Letrozole and tell your doctor.
    Warnings and Precautions

    Please talk to your doctor or pharmacist before taking Letrozole.

        
    if you have severe kidney disease,
        
    if you have severe liver disease,
        
    if you have osteoporosis or fractures (see also "Monitoring your treatment with Letrozole in section 3).

    If any of these statements apply to you, tell your doctor. Your doctor will consider this during your treatment with Letrozole.
    Children and adolescents (under 18 years)

    Children and adolescents should not use Letrozole.
    Older people (age 65 years and older)
    People over the age of 65 years can take Letrozole in the same dosage as other adults.
    Effects of misuse for doping purposes

    The use of Letrozole may give positive results in doping controls. The use of Letrozole as a doping agent may endanger your health.
    Taking Letrozole with other medicines

    Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
    Pregnancy, breast-feeding and fertility

    You should only take Letrozole if you have already had menopause. However, your doctor should discuss the use of effective contraception with you, as you may still be able to get pregnant while taking Letrozole.

    You should not take Letrozole if you are pregnant or breastfeeding because it may harm your baby.
    Driving and using machines

    If you feel dizzy, if you feel drowsy, tired, sleepy or generally uncomfortable, do not drive or operate any tools or machinery that will make you feel comfortable again.
    Letrozole contains lactose

    Letrozole contains lactose (lactose). Please take Letrozole only after consultation with your doctor, if you know that you have a sugar intolerance.

    3. How to take Letrozole?

    Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are not sure. The usual dose is one tablet of Letrozole ratiopharm® 2.5 mg once a day. It will be easier for you to remember to take the tablet if you take Letrozole every day at the same time.

    The tablet may be taken with or without food and should be swallowed whole with a glass of water or other liquid.
    How long does Letrozole take?

    Continue taking Letrozole daily for as long as your doctor tells you to. You may be taking Letrozole for months or even years. If you have questions about how long to take Letrozole, talk to your doctor.
    Monitoring your treatment with Letrozole

    You should only use this medicine under close medical supervision. Your doctor will check you regularly to see if the treatment has the desired effect.

    Letrozole can cause a decrease in bone density by reducing estrogens in your body (osteoporosis). Therefore, your doctor may measure your bone density before, during, and after treatment (a method of checking for osteoporosis).
    If you take more Letrozole than you should

    If you have taken too much Letrozole or if someone else accidentally took your pills, contact your doctor or hospital immediately and ask for advice. Present your tablet pack there. It may be that a medical treatment is required.
    If you forget to take Letrozole

    When it is almost time to take the next tablet (that is, 2 or 3 hours), skip the missed dose and take the next tablet at the scheduled time.
    Otherwise, take the missed tablet as soon as you remember and take the next tablet at the normal time.
    Do not take in twice the amount if you forget to take the previous dose.

    If you stop taking Letrozole

    Do not stop taking Letrozole unless your doctor tells you to do so. Please read further below under "How long does Letrozole take?".

    4. What side effects are possible from Letrozole?

    Like all medicines, this medicine can cause side effects, although not everybody gets them.

    Most side effects are mild to moderate and usually disappear after a few days to weeks of treatment.

    Some of the side effects, such as hot flashes, hair loss, or vaginal bleeding may be due to an estrogen deficiency in your body.

    Do not be worried about the following list of possible side effects. It may be that you do not experience any of these side effects.
    Some side effects could be serious Rare or occasional side effects

    (ie they can affect between 1 and 100 out of 10,000 patients):

        
    Weakness, paralysis, feeling in any area of ​​the body (especially in the arm or leg), coordination problems, nausea, speech or breathing problems (signs of a brain disorder such as stroke)
        
    sudden oppressive pain in the chest (signs of heart disease)
        
    Difficulty breathing, chest pain, fainting, accelerated heartbeat, bluish discoloration or sudden pain in an arm or leg (or foot) (indication that a blood clot may have formed
        
    Swelling and redness along a vein that is extremely painful and possibly sensitive to touch
        
    high fever, chills or mouth ulcers due to infections (lack of white blood cells)
        
    permanently blurred vision.

    Tell your doctor immediately if you experience any of these side effects.

    You should also inform your doctor immediately if you notice any of the following symptoms while using Letrozole:

    Swelling predominantly of the face and throat (signs of allergic reaction)
    Yellow skin and eyes, nausea, loss of appetite, dark colored urine (signs of liver inflammation)
    Skin rash, reddened skin, blistering of lips, eyes or mouth, skin peeling, fever (signs of skin disease).

    Some side effects are very common.

    These side effects can affect more than 10 out of 100 patients.

        
    hot flashes
        
    Elevated cholesterol levels (hypercholesterolemia)
        
    fatigue
        
    Increased sweating
        
    Pain in bones and joints (arthralgia) Tell your doctor if you have any of these side effects.

    Some side effects are common.

    These side effects can affect 1 to 10 in 100 patients.

        
    skin rash
        
    a headache
        
    dizziness
        
    General malaise
        
    Gastrointestinal problems such as nausea, vomiting, upset stomach, constipation, diarrhea
        
    Appetite increase or decrease
        
    Muscle aches
        
    Reduction in bone density (osteoporosis), which can lead to bone fractures in some cases (see also "Monitoring your treatment with Letrozole" in section).
        
    Swelling of arms, hands, feet, ankles (edema / water retention)
        
    Depressed mood (depression)
        
    increase in weight
        
    hair loss
        
    High blood pressure (hypertension)
        
    Abdominal pain
        
    Dry skin
        
    Vaginal bleeding

    Tell your doctor if you have any of these side effects.
    Other side effects are uncommon.

    These side effects can affect between 1 and 10 in 1,000 patients.

        
    Disorders of the nervous system such as anxiety, nervousness, irritability, drowsiness, memory disorders, drowsiness, insomnia
        
    Disorders of the sensation, in particular the touch sensation
        
    Disorders of the eyes like blurred vision, irritation of the eyes
        
    Fast and strong palpitations, fast heartbeat
        
    Skin disorders such as itching (hives)
        
    Vaginal discharge, dry vagina
        
    Joint stiffness (arthritis)
        
    chest pain
        
    fever
        
    Thirst, disorders of taste, dry mouth
        
    Dryness of the mucous membranes
        
    loss in weight
        
    Urinary tract infections, more frequent urinary urgency
        
    to cough
        
    Increase in liver enzyme levels

    Tell your doctor if you have any of these side effects.

    If you notice any side effects, consult your doctor or pharmacist. This also applies to side effects not listed in this leaflet.

    5. How to store Letrozole?

    Store drug out of reach of children.
    Store in the original packaging to protect from moisture.
    You must stop taking Letrozole after the expiry date which is stated on the blister and carton. The expiration date refers to the last day of the month.
    The medicinal product must not be disposed of in waste water or household waste. Ask your pharmacist how to dispose of the medicine when you no longer need it. This measure helps to protect the environment.

  • Mesterolone

    Buy Proviron Mesterolone online

    Proviron® is the Bayer brand name for the oral androgen mesterolone (1-methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can reverse problems of sexual disinterest and impotency, and is sometimes used to increase the amount of sperm. This steroid drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the own body testosterone level in male hardcore bodybuilder`s.

    Although this steroid is strongly androgenic, the anabolic effect of it is pretty good for body building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue also characteristic of dihydrotestosterone. The belief that the anabolic nature of mesterolone indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins Proviron increase the activity of other steroids by displacing a higher percentage into a free usable state. Among extreme bodybuilders Proviron is primarily used as an anti-estrogen. It is believed to act as an anti aromatase in the body, preventing or slowing the conversion of steroids into estrogens. The result is comparable to Arimidex, acting to prevent the buildup of estrogen in the body. This is in direct contrast to tamoxifen, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of tamoxifen is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and tamoxifen, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.

    The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2-methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.

    Proviron® is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolic steroids like Winstrol, Anavar and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of tamoxifen can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).

    The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with tamoxifen (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg tamoxifen daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.

    Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a “safe” oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.

  • Tamoxifen

    1. What is Tamoxifen and what is it used for?

    Tamoxifen belongs to the group of antiestrogens. That is, they counteract the effects of estrogens, the female sex hormones.

    Certain tumors develop under the influence of estrogens. Tamoxifen may inhibit or prevent the development of these tumors.

    Tamoxifen is sometimes used to treat breast cancer.

    2. What do you need to know before using Tamoxifen ?

    Tamoxifen must not be used:

    If you are hypersensitive (allergic) to any of the ingredients of Tamoxifen .
    The ingredients can be found under point 6.
    If you are pregnant, plan to become pregnant or breastfeed.
    You must consult your doctor immediately if you think you may have become pregnant while taking Tamoxifen .

    Take special care with Tamoxifen

    If unusual vaginal blood loss or other gynecological symptoms (such as abdominal pain or pressure) occur when you are taking Tamoxifen or even after discontinuing treatment.
    You must report this to your doctor immediately.
    If you start to experience unusual nausea, vomiting and thirst.
    This may indicate a possible change in the amount of calcium in the blood, and it may be necessary for your doctor to perform certain blood tests.
    If you already belong to the risk group for uterine cancer.
    The risk of developing uterine cancer is increased by the use of tamoxifen.


    3. When using Tamoxifen with other medicines


    Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed. This may be relevant in, for example, blood thinners. Co-administration of tamoxifen with these medicinal products may increase the anticoagulant effect.
    Using Tamoxifen with food and drink

    Not applicable.
    pregnancy and breast feeding period

    Ask your doctor or pharmacist for advice before taking any medicine.

    Observations in experimental animals indicate that tamoxifen has a damaging effect on the fetus. Tamoxifen should not be given during pregnancy. There are no data available on whether tamoxifen passes into breast milk. Therefore, the use of tamoxifen during breast-feeding must be avoided.

    Tamoxifen should not be taken during pregnancy. Some cases of spontaneous miscarriage, birth complications and stillbirth in women treated with tamoxifen have been reported, although no causal relationship has been established.
    Driving and using machines

    Tamoxifen has little or no influence on the ability to drive a vehicle and operate machinery.
    Important information about some of the ingredients of Tamoxifen

    This medicine contains lactose. Please take Tamoxifen only after consultation with your doctor, if you are aware that you have a sugar intolerance.

    4. What side effects are possible from tamoxifen?

    Like all medicines, Tamoxifen can cause side effects, although not everybody gets them.

    The evaluation of adverse reactions is based on the following frequency information:

    Benign, malignant and nonspecific neoplasms (including cysts and polyps)

    Common: transient increase in tumor growth ("tumor flare")

    Diseases of the blood and lymphatic system

    Uncommon: abnormal blood counts: lack of platelets with bruising and bleeding (thrombocytopenia); Lack of white blood cells associated with increased susceptibility to infections (leukopenia and neutropenia) and anemia (anemia).

    Immune system disorders

    Uncommon: Hypersensitivity reactions, including sudden fluid accumulation of the skin and mucous membranes (eg on the throat or tongue), accompanied by difficulty in breathing and / or itching and rash (Quincke's edema).

    Metabolic and nutritional disorders

    Common: Water retention Rare: elevated blood calcium level (hypercalcemia)

    Psychiatric disorders

    Unknown: severe depression over a long period of time (depression)

    Diseases of the nervous system

    Common: headache and dizziness (feeling light-headed)

    eye diseases

    Uncommon: decreased vision due to eye lens (cataract) and / or retina (retinopathy) Rare: decreased vision due to changes in the cornea and some visual disturbances.

    vascular

    Very common: hot flashes Common: formation of blood clots (thromboembolic complications), i.a. Thrombosis of blood vessels and lungs (pulmonary embolism). When Tamoxifen is used in combination with chemotherapy, there is an increased risk of developing thromboembolic complications.

    Respiratory, thoracic and mediastinal disorders

    Very rare: connective tissue inflammation of a pulmonary lobe part (interstitial pneumonia)

    Gastrointestinal disorders

    Common: Tendency to digestive disorders such. Nausea and / or vomiting (gastrointestinal intolerance) Rare: inflammation of the pancreas accompanied by severe upper abdominal pain radiating to the back and nausea (pancreatitis)

    Liver and biliary disorders

    Rare: fatty liver, biliary stasis (cholestasis), hepatitis accompanied by jaundice (yellowing of skin and eyes)

    Skin and subcutaneous tissue disorders

    Very common: sweating increasingly Common: Hair loss, rash / rash Very rare: rash with red irregular patches (erythema multiforme); severe hypersensitivity reaction with (high) fever, red spots on the skin, joint pain and / or eye inflammation (Stevens-Johnson syndrome) and blisters with whitish-yellowish fluid (skin disease: bullous pemphigoid)

    Musculoskeletal, Connective Tissue and Bone Diseases

    Not known: mild joint pain (arthralgia) including joint inflammation (arthritis)

    Diseases of the sexual organs and the mammary gland

    Very common: irregular menstruation Common: absence of menstruation, vaginal blood loss, vaginal discharge, itching of the labia (pruritus vulvae), change in the lining of the uterus, u.a. excessive mucous membrane (hyperplasia) and benign stalk-shaped mucous membrane (polyps) Uncommon: tumor on muscle and connective tissue (fibromyomas) of the uterus, uterine cancer Rare: proliferation of the uterine lining (endometriosis), tumor on the uterus (ovarian cyst), malignant growth on the uterus ( Sarcomas of the uterus, mostly malignant Müller mixed tumors).

    General disorders and administration site conditions

    Not known: tiredness

    investigations

    Common: increased amount of fatty substances (triglycerides) in the blood
    Hypersensitivity reactions:

    Itching, rash, swelling of a blood vessel as a result of an allergic reaction (referred to as Quincke's edema), nettle rash, bronchospasm and very rarely severe hypersensitivity reaction with (high) fever, red spots on the skin, joint pain and / or ophthalmia (as Stevens-Johnson Syndrome).

    If these side effects are severe, it may occasionally be possible to reduce them by reducing the dose (within the recommended interval) while maintaining the drug's effect. If the side effects do not disappear after a dose reduction, treatment may be discontinued.

    If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.


    5. How to store Tamoxifen ?


    Store at room temperature (15 - 25 ° C).

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