Sildenafil

What is Sildenafil viagra?

Viagra or sildenafil will be used to treat adults to men with erectile dysfunction applied. That's the inability, one for a satisfying sexual intercourse to achieve sufficient erection or uphold. sildefanil can only work if a sexual stimulation is present How to use viagra? The recommended dose is 50mg, it is about 1 h...

What is Sildenafil viagra?

Viagra or sildenafil will be used to treat adults to men with erectile dysfunction applied. That's the inability, one for a satisfying sexual intercourse to achieve sufficient erection or uphold. sildefanil can only work if a sexual stimulation is present How to use viagra? The recommended dose is 50mg, it is about 1 hour before sexual intercourse to take it. According to the
sity and compatibility The dose can be reduced increased to 100 mg or reduced to 25 mg
become. The recommended maximum dose is carries 100 mg. The intake must not be frequent.
than once a day. If VIAGRA taken with food is, the impact can be compared be delayed for fasting. Effects of sildenafil? Sildenafil provides an oral treatment of the erectile dysfunction. In a natural way, through sexual stimulation, the impaired erectile function due to an increase in the blood stream into the penis restored. The man responsible for the erection of the penis
The physiological mechanism closes the release of nitric oxide (NO)
in the corpus cavernosum during the se-
xual stimulation. The nitrogen mono-
oxide activates the enzyme guanylate cyclase,
waszuerhöhtenSpiegelnanzyklischem
Guanosine monophosphate (cGMP) leads. Here-
through it comes to a relaxation of
smooth muscles in the corpus cavernosum,
which allows the blood to flow.
Sildenafil is an effective and selective
Inhibitor of the cGMP-specific phosphorus
phodiesterase type 5 (PDE5) in the corpus
vernosum, where they work for the removal of cGMP
responsible for. silde
nafil has a peripheral effect
Erections. Sildenafil does not practice direct
relaxing effect on isolated human
Corpus cavernosum tissue, it
but enhances the relaxing effect
NO on this tissue. If under
sexual stimulation the activation of the
NO / cGMP metabolic pathway takes place,
causes PDE5 inhibition by sildenafil
increased cGMP levels in the corpus cavernos
sum. Therefore, a sexual stimulation
necessary for sildenafil to do the intended
can develop favorable pharmacological effect. Viagra causes a small and temporary
going reduction in blood pressure, which in
in most cases no clinically relevant
Apparitions result. On average,
contributed the maximum blood pressure decreases
lying down after taking 100 mg of Silica
denafil systolic 8.4 mmHg, diastolic
5.5 mmHg. This blood pressure reduction reflects
the vasodilator

 
Effect of sildenafil


reflected, possibly due to increased
cGMP level in the smooth muscle vascular
musculature. Single oral doses of up to 100 mg
Sildenafil showed in healthy volunteers
no clinically relevant ECG changes
gene.
In a study on the hemodynamic
Effects of a single oral dose of
Sildenafil 100 mg in 14 patients with
Severe (> 70% stenosis at least
coronary artery) coronary heart disease
(KHK) took the middle systolic
and the mean diastolic blood pressure in
Rest to the baseline around
7% and 6% respectively. The middle pulmonary
systolic blood pressure decreased by 9%.
Sildenafil did not affect the cardiac
it still affected the
Blood flow into the stenosed coronary
arteries.
In a double-blind placebo-controlled
The load study included 144 patients
with erectile dysfunction and stable chro
angina pectoris, the
antianginal medication (except
Nitrates). Under sildenafil occurred in the
Compared to placebo, no clinically relevant
differences in the time to
Occur an abortion-compelling angina.

Side effects of viagra?

Summary of the security profile
The safety profile of VIAGRA is based on
9,570 patients from 74 double-blind place-
bokontrollierten clinical trials. The most commonly described side effects
in patients treated with sildenafil
in clinical trials were headaches,
Flush, dyspepsia, stuffy nose, dizziness
del, nausea, hot flash, blurred vision,
Cyanopsia and blurred vision.      

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